The Smithsonian American Art Museum and National Portrait Gallery share the Nan Tucker McEvoy Auditorium, a 346-seat facility located on the building's lower level. Public programming includes lectures and films as well as music, theater and dance performances. The auditorium is fully accessible from the lobby of the G Street entrance for after-hours events and performances. For information on upcoming programs, visit The Reynold's Center calendar.

The National Historic Landmark building that houses the Nan Tucker McEvoy Auditorium is also home to the Smithsonian American Art Museum (SAAM), the Smithsonian National Portrait Gallery,  the Lunder Conservation Center, the Luce Foundation Center for American Art, and the Robert and Arlene Kogod Courtyard.